MGP Database

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MGP004925

UniProt Annotations

Entry Information
Gene Namepotassium channel, voltage gated eag related subfamily H, member 5
Protein EntryKCNH5_HUMAN
UniProt IDQ8NCM2
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; IsoId=Q8NCM2-1; Sequence=Displayed; Name=2; Synonyms=2b; IsoId=Q8NCM2-2; Sequence=VSP_000973, VSP_000974; Name=3; IsoId=Q8NCM2-3; Sequence=VSP_000972, VSP_000975, VSP_000976;
DomainThe segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
FunctionPore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly.
Sequence CautionSequence=BAC11016.1; Type=Erroneous termination; Positions=436; Note=Translated as Gly.; Evidence={ECO:0000305};
SimilarityBelongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv10.2/KCNH5 sub-subfamily. {ECO:0000305}.
SimilarityContains 1 cyclic nucleotide-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00060}.
SimilarityContains 1 PAC (PAS-associated C-terminal) domain. {ECO:0000255|PROSITE-ProRule:PRU00141}.
SimilarityContains 1 PAS (PER-ARNT-SIM) domain. {ECO:0000305}.
Subcellular LocationMembrane; Multi-pass membrane protein.
SubunitThe potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH1/EAG (Probable). {ECO:0000305}.
Tissue SpecificityDetected in brain, skeletal muscle, heart, placenta, lung and liver, and at low levels in kidney.
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