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MGP004968

UniProt Annotations

Entry Information
Gene Namemethionine adenosyltransferase II, beta
Protein EntryMAT2B_HUMAN
UniProt IDQ9NZL9
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q9NZL9-1; Sequence=Displayed; Name=2; IsoId=Q9NZL9-2; Sequence=VSP_025534; Name=3; IsoId=Q9NZL9-3; Sequence=VSP_025538, VSP_025539; Note=No experimental confirmation available.; Name=4; IsoId=Q9NZL9-4; Sequence=VSP_025534, VSP_025540; Name=5; IsoId=Q9NZL9-5; Sequence=VSP_025535, VSP_025536, VSP_025537;
FunctionNon-catalytic regulatory subunit of S-adenosylmethionine synthetase 2 (MAT2A), an enzyme that catalyzes the formation of S- adenosylmethionine from methionine and ATP. Regulates the activity of S-adenosylmethionine synthetase 2 by changing its kinetic properties, rendering the enzyme more susceptible to S- adenosylmethionine inhibition. {ECO:0000269|PubMed:10644686}.
MiscellaneousIts expression in hepatoma cell lines may lead to increase DNA synthesis and thereby participate in cell proliferation.
PathwayAmino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.
Sequence CautionSequence=AAG39296.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily. {ECO:0000305}.
SubunitHeterotetramer composed of 2 catalytic alpha subunits (alpha and alpha') (MAT2A) and 1 copy of beta subunit (MAT2B). {ECO:0000269|PubMed:10644686}.
Tissue SpecificityWidely expressed. {ECO:0000269|PubMed:10644686, ECO:0000269|PubMed:11337507}.
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