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MGP004970

Record overview

MGPD IDMGP004970
Gene ID28234
SpeciesHomo sapiens (Human)
Gene Namesolute carrier organic anion transporter family, member 1B3
Gene Symbol SLCO1B3
SynonymsLST3; HBLRR; LST-2; OATP8; OATP-8; OATP1B3; SLC21A8; LST-3TM13;
Alternate namessolute carrier organic anion transporter family member 1B3; liver-specific organic anion transporter 2; liver-specific organic anion transporter 3TM13; organic anion transporter 8; organic anion transporter LST-3c; organic anion-transporting polypeptide 8; solute carrier family 21 (organic anion transporter), member 8;
Chromosome12
Map Location12p12
SummaryThis gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type hyperbilirubinemia. [provided by RefSeq, Feb 2012]
OrthologsView orthologs and multiple alignments for SLCO1B3

Proteins

solute carrier organic anion transporter family member 1B3
Refseq ID:NP_062818
Protein GI:9790233
UniProt ID:Q9NPD5
mRNA ID:NM_019844
Length:702
RefSeq Status:
MDQHQHLNKTAESASSEKKKTRRCNGFKMFLAALSFSYIAKALGGIIMKISITQIERRFDISSSLAGLIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIG
CLLMGTGSILTSLPHFFMGYYRYSKETHINPSENSTSSLSTCLINQTLSFNGTSPEIVEKDCVKESGSHMWIYVFMGNMLRGIGETPIVPLGISYIDDFA
KEGHSSLYLGSLNAIGMIGPVIGFALGSLFAKMYVDIGYVDLSTIRITPKDSRWVGAWWLGFLVSGLFSIISSIPFFFLPKNPNKPQKERKISLSLHVLK
TNDDRNQTANLTNQGKNVTKNVTGFFQSLKSILTNPLYVIFLLLTLLQVSSFIGSFTYVFKYMEQQYGQSASHANFLLGIITIPTVATGMFLGGFIIKKF
KLSLVGIAKFSFLTSMISFLFQLLYFPLICESKSVAGLTLTYDGNNSVASHVDVPLSYCNSECNCDESQWEPVCGNNGITYLSPCLAGCKSSSGIKKHTV
FYNCSCVEVTGLQNRNYSAHLGECPRDNTCTRKFFIYVAIQVINSLFSATGGTTFILLTVKIVQPELKALAMGFQSMVIRTLGGILAPIYFGALIDKTCM
KWSTNSCGAQGACRIYNSVFFGRVYLGLSIALRFPALVLYIVFIFAMKKKFQGKDTKASDNERKVMDEANLEFLNNGEHFVPSAGTDSKTCNLDMQDNAA
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