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MGP004989

Record overview

MGPD IDMGP004989
Gene ID29082
SpeciesHomo sapiens (Human)
Gene Namecharged multivesicular body protein 4A
Gene Symbol CHMP4A
SynonymsSNF7; CHMP4; SHAX2; CHMP4B; SNF7-1; VPS32A; HSPC134; VPS32-1; C14orf123;
Alternate namescharged multivesicular body protein 4a; SNF7 homolog associated with Alix-2; Snf7 homologue associated with Alix 2; chromatin modifying protein 4A; vacuolar protein sorting-associated protein 32-1;
Chromosome14
Map Location14q12
SummaryCHMP4A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]
OrthologsView orthologs and multiple alignments for CHMP4A

Proteins

charged multivesicular body protein 4a
Refseq ID:NP_054888
Protein GI:40548422
UniProt ID:Q9BY43
mRNA ID:NM_014169
Length:265
RefSeq Status:
MSRRRPEDGLGKAGPCVMRHHPPRSKAEVWRTLRGGGGRGELAMSGLGRLFGKGKKEKGPTPEEAIQKLKETEKILIKKQEFLEQKIQQELQTAKKYGTK
NKRAALQALRRKKRFEQQLAQTDGTLSTLEFQREAIENATTNAEVLRTMELAAQSMKKAYQDMDIDKVDELMTDITEQQEVAQQISDAISRPMGFGDDVD
EDELLEELEELEQEELAQELLNVGDKEEEPSVKLPSVPSTHLPAGPAPKVDEDEEALKQLAEWVS
 
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