MGP Database

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MGP005023

UniProt Annotations

Entry Information
Gene Nametranslocase of inner mitochondrial membrane 22 homolog (yeast)
Protein EntryTIM22_HUMAN
UniProt IDQ9Y584
SpeciesHuman
Comments
Comment typeDescription
FunctionEssential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity). {ECO:0000250}.
SimilarityBelongs to the Tim17/Tim22/Tim23 family. {ECO:0000305}.
Subcellular LocationMitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
SubunitComponent of the TIM22 complex, whose core is composed of TIMM22, associated with peripheral protein FXC1/TIM10B and the 70 kDa heterohexamer. In most cases, the 70 kDa complex is composed of TIMM9 and TIMM10. A small fraction of the 70 kDa complex is composed of TIM8 (TIMM8A/DDP1 or TIMM8B/DDP2) and TIMM13. Interacts directly with TIMM9, TIMM10/TIM10A and FXC1/TIM10B. {ECO:0000269|PubMed:14726512}.
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