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MGP Database

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MGP005045

UniProt Annotations

Entry Information

Gene Name	egf-like module containing, mucin-like, hormone receptor-like 2
Protein Entry	EMR2_HUMAN
UniProt ID	Q9UHX3
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=6; Comment=A number of isoforms are probably produced. A soluble form due to a frameshift which introduced a stop codon immediately before the first TM domain is also detected.; Name=1; IsoId=Q9UHX3-1; Sequence=Displayed; Name=2; IsoId=Q9UHX3-2; Sequence=VSP_041367; Name=3; IsoId=Q9UHX3-3; Sequence=VSP_041366; Name=4; IsoId=Q9UHX3-4; Sequence=VSP_041365; Name=5; IsoId=Q9UHX3-5; Sequence=VSP_041364; Name=6; IsoId=Q9UHX3-6; Sequence=VSP_047535; Note=No experimental confirmation available.;
Domain	Binding to chondroitin sulfate is mediated by the fourth EGF domain.
Domain	The GPS domain is necessary, but not sufficient for receptor cleavage, which require the entire extracellular stalk.
Function	Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. {ECO:0000269\|PubMed:12829604, ECO:0000269\|PubMed:17928360, ECO:0000269\|PubMed:22310662}.
Ptm	Autoproteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane beta subunit. {ECO:0000269\|PubMed:12860403}.
Sequence Caution	Sequence=BAC06146.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity	Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. {ECO:0000305}.
Similarity	Contains 1 GPS domain. {ECO:0000255\|PROSITE- ProRule:PRU00098}.
Similarity	Contains 5 EGF-like domains. {ECO:0000255\|PROSITE- ProRule:PRU00076}.
Subcellular Location	Cell membrane; Multi-pass membrane protein. Cell projection, ruffle membrane; Multi-pass membrane protein. Note=Localized at the leading edge of migrating cells.
Subunit	Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety. Interacts with chondroitin sulfate; the interaction with chondroitin sulfate is calcium-dependent. Interacts with CD55. {ECO:0000269\|PubMed:12829604, ECO:0000269\|PubMed:15150276, ECO:0000269\|PubMed:17449467}.
Tissue Specificity	Expression is restricted to myeloid cells. Highest expression was found in peripheral blood leukocytes, followed by spleen and lymph nodes, with intermediate to low levels in thymus, bone marrow, fetal liver, placenta, and lung, and no expression in heart, brain, skeletal muscle, kidney, or pancreas. Expression is also detected in monocyte/macrophage and Jurkat cell lines but not in other cell lines tested. {ECO:0000269\|PubMed:10903844, ECO:0000269\|PubMed:11994511}.