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MGP005049

UniProt Annotations

Entry Information
Gene NameEH-domain containing 3
Protein EntryEHD3_HUMAN
UniProt IDQ9NZN3
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NZN3-1; Sequence=Displayed; Name=2; IsoId=Q9NZN3-2; Sequence=VSP_056606, VSP_056607; Note=No experimental confirmation available.;
DomainThe EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins. {ECO:0000250}.
FunctionPlays a role in endocytic transport. {ECO:0000269|PubMed:16251358, ECO:0000269|PubMed:17233914}.
Sequence CautionSequence=AAF40471.1; Type=Frameshift; Positions=527; Evidence={ECO:0000305};
SimilarityBelongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. EHD subfamily. {ECO:0000305}.
SimilarityContains 1 dynamin-type G (guanine nucleotide-binding) domain. {ECO:0000305}.
SimilarityContains 1 EF-hand domain. {ECO:0000255|PROSITE- ProRule:PRU00448}.
SimilarityContains 1 EH domain. {ECO:0000255|PROSITE- ProRule:PRU00077}.
Subcellular LocationCell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Cytoplasm {ECO:0000250}.
SubunitHomooligomer, and heterooligomer with EHD1, EHD2 and EHD4, ATP-binding is required for heterooligomerization. Interacts with PACSIN1 and PACSIN2. Interacts (via EH domain) with MICALL1. Interacts (via EH domain) with RAB11FIP2. {ECO:0000269|PubMed:16251358, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:18331452, ECO:0000269|PubMed:19864458}.
Tissue SpecificityHighly expressed in heart and brain and moderately expressed in kidney, liver, and placenta.
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