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MGP005054

UniProt Annotations

Entry Information

Gene Name	G0/G1 switch 2
Protein Entry	G0S2_HUMAN
UniProt ID	P27469
Species	Human

Comments

Comment type	Description
Function	Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers. {ECO:0000269\|PubMed:19706769}.
Induction	Induced by TNF through the activation of the NFKB pathway. {ECO:0000269\|PubMed:19706769}.
Subcellular Location	Mitochondrion {ECO:0000269\|PubMed:19706769}.
Subunit	Directly interacts with BCL2; this interaction prevents the formation of the anti-apoptotic BAX-BCL2 complex. {ECO:0000269\|PubMed:19706769}.
Tissue Specificity	Widely expressed with highest levels in peripheral blood, skeletal muscle and heart, followed by kidney and liver. {ECO:0000269\|PubMed:19706769}.