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MGP005072

UniProt Annotations

Entry Information
Gene Nameretinol dehydrogenase 8 (all-trans)
Protein EntryRDH8_HUMAN
UniProt IDQ9NYR8
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityAll-trans-retinol + NADP(+) = all-trans- retinal + NADPH.
FunctionRetinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity (By similarity). {ECO:0000250}.
Sequence CautionSequence=BAB14782.1; Type=Frameshift; Positions=26; Evidence={ECO:0000305};
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue SpecificityDetected in photoreceptor outer segments in the retina (at protein level). {ECO:0000269|PubMed:10753906}.
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