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MGP005073

UniProt Annotations

Entry Information
Gene NameArfGAP with SH3 domain, ankyrin repeat and PH domain 1
Protein EntryASAP1_HUMAN
UniProt IDQ9ULH1
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=2; IsoId=Q9ULH1-1; Sequence=Displayed; Name=1; IsoId=Q9ULH1-2; Sequence=VSP_008365;
DomainThe PH domain most probably contributes to the phosphoinositide-dependent regulation of ADP ribosylation factors. {ECO:0000250}.
Enzyme RegulationActivity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2). {ECO:0000250}.
FunctionPossesses phosphatidylinositol 4,5-bisphosphate- dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity). Plays a role in ciliogenesis. {ECO:0000250, ECO:0000269|PubMed:20393563}.
InteractionP70039:apc (xeno); NbExp=5; IntAct=EBI-346622, EBI-8069633; Q13191:CBLB; NbExp=2; IntAct=EBI-346622, EBI-744027; P46108:CRK; NbExp=2; IntAct=EBI-346622, EBI-886; Q14247:CTTN; NbExp=7; IntAct=EBI-346622, EBI-351886; P06241:FYN; NbExp=3; IntAct=EBI-346622, EBI-515315; P62993:GRB2; NbExp=7; IntAct=EBI-346622, EBI-401755; P08631:HCK; NbExp=2; IntAct=EBI-346622, EBI-346340; P16333:NCK1; NbExp=6; IntAct=EBI-346622, EBI-389883; P19174:PLCG1; NbExp=3; IntAct=EBI-346622, EBI-79387; Q96B97:SH3KBP1; NbExp=8; IntAct=EBI-346622, EBI-346595; P12931:SRC; NbExp=3; IntAct=EBI-346622, EBI-621482; P0CG48:UBC; NbExp=2; IntAct=EBI-346622, EBI-3390054;
PtmPhosphorylated on tyrosine residues by SRC. {ECO:0000250}.
SimilarityContains 1 Arf-GAP domain. {ECO:0000255|PROSITE- ProRule:PRU00288}.
SimilarityContains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
SimilarityContains 1 SH3 domain. {ECO:0000255|PROSITE- ProRule:PRU00192}.
SimilarityContains 2 ANK repeats. {ECO:0000255|PROSITE- ProRule:PRU00023}.
Subcellular LocationCytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Note=Predominantly cytoplasmic. Partially membrane- associated. {ECO:0000250}.
SubunitHomodimer. Interacts with SRC and CRK. Interacts with RAB11FIP3. Interacts with PTK2B/PYK2 (By similarity). Interacts with CTTN. Interacts (via SH3 domain) with APC. {ECO:0000250, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:20509626}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ASAP1ID44351ch8q24.html";
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