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MGP005074

UniProt Annotations

Entry Information
Gene Nameadenylate kinase 3
Protein EntryQ7Z4Y4_HUMAN
UniProt IDQ7Z4Y4
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityNTP + AMP = NDP + ADP. {ECO:0000256|HAMAP- Rule:MF_03169}.
DomainConsists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis. {ECO:0000256|HAMAP- Rule:MF_03169}.
FunctionInvolved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. {ECO:0000256|HAMAP-Rule:MF_03169}.
SimilarityBelongs to the adenylate kinase family. AK3 subfamily. {ECO:0000256|HAMAP-Rule:MF_03169}.
SimilarityBelongs to the adenylate kinase family. {ECO:0000256|RuleBase:RU003330}.
Subcellular LocationMitochondrion matrix {ECO:0000256|HAMAP- Rule:MF_03169}.
SubunitMonomer. {ECO:0000256|HAMAP-Rule:MF_03169}.
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