MGP Database

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MGP005088

UniProt Annotations

Entry Information
Gene Nameheme binding protein 1
Protein EntryHEBP1_HUMAN
UniProt IDQ9NRV9
SpeciesHuman
Comments
Comment typeDescription
DomainForms a distorted beta-barrel structure, with two helices that are packed against the outer surface of the barrel. Porphyrins are expected to bind to a hydrophobic patch on the outer surface of the beta-barrel structure (By similarity). {ECO:0000250}.
FunctionMay bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N- methylprotoporphyrin with similar affinities. {ECO:0000269|PubMed:12413491}.
SimilarityBelongs to the HEBP family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:12413491}.
SubunitMonomer. {ECO:0000269|PubMed:12413491}.
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