MGP Database

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MGP005094

UniProt Annotations

Entry Information
Gene Nameamidohydrolase domain containing 2
Protein EntryNAGA_HUMAN
UniProt IDQ9Y303
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9Y303-1; Sequence=Displayed; Name=2; IsoId=Q9Y303-2; Sequence=VSP_030698; Name=3; IsoId=Q9Y303-3; Sequence=VSP_030698, VSP_038782;
Catalytic ActivityN-acetyl-D-glucosamine 6-phosphate + H(2)O = D-glucosamine 6-phosphate + acetate. {ECO:0000269|PubMed:22692205}.
CofactorName=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence={ECO:0000250}; Note=Binds 1 divalent metal cation per subunit. {ECO:0000250};
FunctionHydrolyzes the N-glycolyl group from N- glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N- glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. {ECO:0000269|PubMed:22692205}.
PathwayAmino-sugar metabolism; N-acetylneuraminate degradation. {ECO:0000269|PubMed:22692205}.
Sequence CautionSequence=AAD27723.1; Type=Frameshift; Positions=5, 7, 11, 103, 113, 117, 192, 194, 195, 202, 205; Evidence={ECO:0000305};
SimilarityBelongs to the NagA family. {ECO:0000305}.
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