MGP Database

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MGP005100

UniProt Annotations

Entry Information
Gene Namepresequence translocase-associated motor 16 homolog (S. cerevisiae)
Protein EntryTIM16_HUMAN
UniProt IDQ9Y3D7
SpeciesHuman
Comments
Comment typeDescription
DomainThe J-like region, although related to the J domain does not have co-chaperone activity. {ECO:0000250}.
FunctionRegulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity. {ECO:0000269|PubMed:20053669}.
InductionBy CSF2/GM-CSF.
SimilarityBelongs to the TIM16/PAM16 family. {ECO:0000305}.
Subcellular LocationMitochondrion inner membrane {ECO:0000269|PubMed:11750097, ECO:0000269|PubMed:20053669}; Peripheral membrane protein {ECO:0000269|PubMed:11750097, ECO:0000269|PubMed:20053669}; Matrix side {ECO:0000269|PubMed:11750097, ECO:0000269|PubMed:20053669}.
SubunitProbable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19 (By similarity). Interacts with DNAJC19. Directly interacts with DNAJC15; this interaction counteracts DNAJC15-dependent stimulation of HSPA9 ATPase activity. Associates with the TIM23 complex. {ECO:0000250, ECO:0000269|PubMed:20053669, ECO:0000269|PubMed:23263864}.
Tissue SpecificityUbiquitously expressed. {ECO:0000269|PubMed:15704001}.
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