MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP005109

UniProt Annotations

Entry Information
Gene Namedeoxyribose-phosphate aldolase (putative)
Protein EntryDEOC_HUMAN
UniProt IDQ9Y315
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity2-deoxy-D-ribose 5-phosphate = D- glyceraldehyde 3-phosphate + acetaldehyde. {ECO:0000269|PubMed:25229427}.
FunctionCatalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation. {ECO:0000269|PubMed:25229427}.
InteractionQ9BRP4:PAAF1; NbExp=1; IntAct=EBI-1048152, EBI-1056358;
PathwayCarbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2- deoxy-alpha-D-ribose 1-phosphate: step 2/2.
Sequence CautionSequence=AAD27735.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH56234.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD96261.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:25229427}. Cytoplasmic granule {ECO:0000269|PubMed:25229427}. Nucleus {ECO:0000269|PubMed:25229427}. Note=Recruited to stress granules but not to processing bodies upon arsenite or clotrimazole treatment or energy deprivation. {ECO:0000269|PubMed:25229427}.
SubunitInteracts with YBX1. {ECO:0000269|PubMed:25229427}.
Tissue SpecificityMainly expressed in liver, lung and colon. {ECO:0000269|PubMed:25229427}.
  logo