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MGP005119

UniProt Annotations

Entry Information
Gene Namemitochondrial trans-2-enoyl-CoA reductase
Protein EntryMECR_HUMAN
UniProt IDQ9BV79
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BV79-1; Sequence=Displayed; Name=2; Synonyms=cMECR; IsoId=Q9BV79-2; Sequence=VSP_041131;
Biophysicochemical PropertiesKinetic parameters: KM=37 uM for trans-2-hexenoyl-CoA {ECO:0000269|PubMed:12654921, ECO:0000269|PubMed:18479707}; KM=7.1 uM for trans-2-decenoyl-CoA {ECO:0000269|PubMed:12654921, ECO:0000269|PubMed:18479707}; KM=3.6 uM for trans-dodec-2-enoyl-CoA {ECO:0000269|PubMed:12654921, ECO:0000269|PubMed:18479707}; KM=10.4 uM for trans-dec-2-enoyl-CoA {ECO:0000269|PubMed:12654921, ECO:0000269|PubMed:18479707}; KM=10.2 uM for trans-oct-2-enoyl-CoA {ECO:0000269|PubMed:12654921, ECO:0000269|PubMed:18479707}; KM=4.3 uM for trans-tetradec-2-enoyl-CoA {ECO:0000269|PubMed:12654921, ECO:0000269|PubMed:18479707}; KM=6.6 uM for trans-hexadec-2-enoyl-CoA {ECO:0000269|PubMed:12654921, ECO:0000269|PubMed:18479707}; KM=63.5 uM for trans-hex-2-enoyl-CoA {ECO:0000269|PubMed:12654921, ECO:0000269|PubMed:18479707};
Catalytic ActivityAcyl-CoA + NADP(+) = trans-2,3-dehydroacyl-CoA + NADPH. {ECO:0000269|PubMed:12654921, ECO:0000269|PubMed:18479707}.
FunctionOxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2- decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis. {ECO:0000269|PubMed:18479707}.
Sequence CautionSequence=AAD34058.1; Type=Frameshift; Positions=14, 19; Evidence={ECO:0000305};
SimilarityBelongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. {ECO:0000305}.
Subcellular LocationIsoform 1: Mitochondrion {ECO:0000269|PubMed:12654921}.
Subcellular LocationIsoform 2: Cytoplasm {ECO:0000269|PubMed:25031892}. Nucleus {ECO:0000269|PubMed:25031892}.
SubunitHomodimer. Isoform 2 interacts with PPARA in the nucleus and increases its activity. {ECO:0000250|UniProtKB:Q9Z311, ECO:0000269|PubMed:12654921, ECO:0000269|PubMed:18479707}.
Tissue SpecificityHighly expressed in skeletal and heart muscle. Expressed at lower level in placenta, liver, kidney and pancreas. Weakly or not expressed in lung. {ECO:0000269|PubMed:12654921}.
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