MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP005122

UniProt Annotations

Entry Information
Gene Nameretinol dehydrogenase 11 (all-trans/9-cis/11-cis)
Protein EntryRDH11_HUMAN
UniProt IDQ8TC12
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8TC12-1; Sequence=Displayed; Name=2; IsoId=Q8TC12-2; Sequence=VSP_008159; Note=No experimental confirmation available.; Name=3; IsoId=Q8TC12-3; Sequence=VSP_046403; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=0.23 uM for NADPH {ECO:0000269|PubMed:12036956}; KM=0.8 uM for NADP {ECO:0000269|PubMed:12036956}; KM=0.5 uM for all-trans-retinal {ECO:0000269|PubMed:12036956}; KM=0.62 uM for 13-cis-retinal {ECO:0000269|PubMed:12036956}; KM=0.19 uM for 9-cis-retinal {ECO:0000269|PubMed:12036956}; KM=1.3 uM for all-trans-retinol {ECO:0000269|PubMed:12036956}; Vmax=18 nmol/min/mg enzyme with all-trans-retinal as substrate {ECO:0000269|PubMed:12036956}; Vmax=7 nmol/min/mg enzyme with 13-cis-retinal as substrate {ECO:0000269|PubMed:12036956}; Vmax=1.6 nmol/min/mg enzyme with 9-cis-retinal as substrate {ECO:0000269|PubMed:12036956}; Vmax=0.95 nmol/min/mg enzyme with all-trans-retinol as substrate {ECO:0000269|PubMed:12036956}; Note=Vmax is measured per mg microsomal protein.;
Catalytic ActivityAll-trans-retinol + NADP(+) = all-trans- retinal + NADPH. {ECO:0000269|PubMed:12036956}.
FunctionExhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity towards 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected.
InductionBy androgens in prostate cancer cells.
PtmNot glycosylated.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:12036956}; Single-pass type II membrane protein {ECO:0000269|PubMed:12036956}.
Tissue SpecificityPredominantly expressed in the epithelial cells of prostate, in both basal and luminal secretory cell populations. Expressed at low levels in spleen, thymus, testis, ovary, small intestine, colon, peripherical blood leukocytes, kidney, adrenal gland and fetal liver. Not detected in prostatic fibromuscular stromal cells, endothelial cells, or infiltrating lymphocytes.
  logo