MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP005135

Ontology/Pathway Information

Entrez Gene ID51191
Gene NameHECT and RLD domain containing E3 ubiquitin protein ligase 5
Gene Symbol HERC5
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IBA:GO_CentralCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0005634 IBA:GO_CentralCnucleus
GO:0048471 IEA:UniProtKB-SubCellCperinuclear region of cytoplasm
GO:0042296 IDA:UniProtKBFISG15 transferase activity
GO:0016874 IEA:UniProtKB-KWFligase activity
GO:0044822 IDA:UniProtKBFpoly(A) RNA binding
GO:0004842 IBA:GO_CentralFubiquitin-protein transferase activity
GO:0019221 TAS:ReactomePcytokine-mediated signaling pathway
GO:0051607 IEA:UniProtKB-KWPdefense response to virus
GO:0045087 TAS:ReactomePinnate immune response
GO:0032020 IDA:UniProtKBPISG15-protein conjugation
GO:0032480 TAS:ReactomePnegative regulation of type I interferon production
GO:0042787 IBA:GO_CentralPprotein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0000079 TAS:ProtIncPregulation of cyclin-dependent protein serine/threonine kinase activity
GO:0050688 IDA:UniProtKBPregulation of defense response to virus
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_115676Antiviral mechanism by IFN-stimulated genes
REACT_75790Cytokine Signaling in Immune system
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_25229Interferon Signaling
REACT_115831ISG15 antiviral mechanism
REACT_25271Negative regulators of RIG-I/MDA5 signaling
REACT_25359RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
  logo