MGP Database

MGP005155

Record overview

MGPD ID	MGP005155
Gene ID	51293
Species	Homo sapiens (Human)
Gene Name	CD320 molecule
Gene Symbol	CD320
Synonyms	8D6; 8D6A; TCBLR;
Alternate names	CD320 antigen; 8D6 antigen; FDC-SM-8D6; FDC-signaling molecule 8D6; transcobalamin receptor;
Chromosome	19
Map Location	19p13.3-p13.2
Summary	This gene encodes the transcobalamin receptor that is expressed at the cell surface. It mediates the cellular uptake of transcobalamin bound cobalamin (vitamin B12), and is involved in B-cell proliferation and immunoglobulin secretion. Mutations in this gene are associated with methylmalonic aciduria. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]
Orthologs	View orthologs and multiple alignments for CD320

Proteins

CD320 antigen isoform 1 precursor

Refseq ID:	NP_057663
Protein GI:	7706111
UniProt ID:	Q9NPF0
mRNA ID:	NM_016579
Length:	282
RefSeq Status:

`MSGGWMAQVGAWRTGALGLALLLLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQC PPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATTMGPPVTLESVTSLRNATTMG PPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSASLVTATLLLLSWLRAQERLRPLGLLVAMKESLLLSEQKTSLP`

sig_peptide: 1..30
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2984
peptide sequence: 
MSGGWMAQVGAWRTGALGLALLLLLGLGLG

mat_peptide: 31..240
product: CD320 antigen isoform 2
calculated_mol_wt: 21405
peptide sequence: 
LEAAASPLSTPTSAQAAGIEPCTQKGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEI
LPEGDATTMGPPVTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSASLVTATLLLLSWLRAQERLRPLGLLVAMKESL
LLSEQKTSLP

sig_peptide: 1..30
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2984
peptide sequence: 
MSGGWMAQVGAWRTGALGLALLLLLGLGLG

mat_peptide: 31..282
product: CD320 antigen isoform 1
calculated_mol_wt: 26026
peptide sequence: 
LEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRL
ACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATTMGPPVTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYG
VIAAAAVLSASLVTATLLLLSWLRAQERLRPLGLLVAMKESLLLSEQKTSLP

CD320 antigen isoform 2 precursor

Refseq ID:	NP_001159367
Protein GI:	259906403
UniProt ID:	Q9NPF0
mRNA ID:	NM_001165895
Length:	240
RefSeq Status:

`MSGGWMAQVGAWRTGALGLALLLLLGLGLGLEAAASPLSTPTSAQAAGIEPCTQKGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLS DDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATTMGPPVTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSASL VTATLLLLSWLRAQERLRPLGLLVAMKESLLLSEQKTSLP`

sig_peptide: 1..30
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2984
peptide sequence: 
MSGGWMAQVGAWRTGALGLALLLLLGLGLG

mat_peptide: 31..240
product: CD320 antigen isoform 2
calculated_mol_wt: 21405
peptide sequence: 
LEAAASPLSTPTSAQAAGIEPCTQKGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEI
LPEGDATTMGPPVTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSASLVTATLLLLSWLRAQERLRPLGLLVAMKESL
LLSEQKTSLP