MGP Database

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MGP005163

UniProt Annotations

Entry Information
Gene Namesolute carrier family 25 (mitochondrial iron transporter), member 37
Protein EntryMFRN1_HUMAN
UniProt IDQ9NYZ2
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9NYZ2-1; Sequence=Displayed; Name=2; IsoId=Q9NYZ2-2; Sequence=VSP_018402, VSP_018403; Name=4; IsoId=Q9NYZ2-4; Sequence=VSP_018400; Note=No experimental confirmation available.;
FunctionMitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity). {ECO:0000250}.
Sequence CautionSequence=AAF64141.1; Type=Frameshift; Positions=296; Evidence={ECO:0000305}; Sequence=CAH10415.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
SimilarityBelongs to the mitochondrial carrier (TC 2.A.29) family. {ECO:0000305}.
SimilarityContains 3 Solcar repeats. {ECO:0000255|PROSITE- ProRule:PRU00282}.
Subcellular LocationMitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
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