MGP Database

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MGP005168

Ontology/Pathway Information

Entrez Gene ID51339
Gene Namedishevelled-binding antagonist of beta-catenin 1
Gene Symbol DACT1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0030877 IDA:UniProtKBCbeta-catenin destruction complex
GO:0030054 IEA:UniProtKB-KWCcell junction
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005654 IDA:HPACnucleoplasm
GO:0045202 IEA:UniProtKB-SubCellCsynapse
GO:0008013 IDA:UniProtKBFbeta-catenin binding
GO:0070097 ISS:UniProtKBFdelta-catenin binding
GO:0051018 IDA:UniProtKBFprotein kinase A binding
GO:0005080 ISS:UniProtKBFprotein kinase C binding
GO:0048813 IEA:EnsemblPdendrite morphogenesis
GO:0048619 ISS:UniProtKBPembryonic hindgut morphogenesis
GO:0001702 IEA:EnsemblPgastrulation with mouth forming second
GO:0090090 IEA:EnsemblPnegative regulation of canonical Wnt signaling pathway
GO:2000134 IDA:UniProtKBPnegative regulation of G1/S transition of mitotic cell cycle
GO:0046329 IDA:UniProtKBPnegative regulation of JNK cascade
GO:0000122 IDA:UniProtKBPnegative regulation of transcription from RNA polymerase II promoter
GO:0030178 IDA:UniProtKBPnegative regulation of Wnt signaling pathway
GO:0035413 IMP:UniProtKBPpositive regulation of catenin import into nucleus
GO:0045600 IEA:EnsemblPpositive regulation of fat cell differentiation
GO:0045732 IDA:MGIPpositive regulation of protein catabolic process
GO:0030177 IDA:UniProtKBPpositive regulation of Wnt signaling pathway
GO:0035412 IMP:UniProtKBPregulation of catenin import into nucleus
GO:0031647 IDA:UniProtKBPregulation of protein stability
GO:2000095 ISS:UniProtKBPregulation of Wnt signaling pathway, planar cell polarity pathway
GO:0050808 IEA:EnsemblPsynapse organization
GO:0016055 IEA:UniProtKB-KWPWnt signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_264438degradation of DVL
REACT_116125Disease
REACT_264594misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
REACT_264378RNF mutants show enhanced WNT signaling and proliferation
REACT_11045Signaling by Wnt
REACT_264125Signaling by WNT in cancer
REACT_111102Signal Transduction
REACT_264596TCF dependent signaling in response to WNT
REACT_264356XAV939 inhibits tankyrase, stabilizing AXIN
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