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MGP Database

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MGP005177

UniProt Annotations

Entry Information

Gene Name	ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
Protein Entry	VATD_HUMAN
UniProt ID	Q9Y5K8
Species	Human

Comments

Comment type	Description
Function	Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. {ECO:0000250, ECO:0000269\|PubMed:21844891}.
Similarity	Belongs to the V-ATPase D subunit family. {ECO:0000305}.
Subcellular Location	Membrane {ECO:0000305\|PubMed:21844891}; Peripheral membrane protein {ECO:0000305\|PubMed:21844891}; Cytoplasmic side {ECO:0000305\|PubMed:21844891}. Note=Localizes to centrosome and the base of the cilium.
Subunit	V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d). Interacts with SNX10; may play a role in ciliogenesis. {ECO:0000269\|PubMed:21844891}.