MGP Database

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MGP005179

UniProt Annotations

Entry Information
Gene Namezinc finger protein 589
Protein EntryZN589_HUMAN
UniProt IDQ86UQ0
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q86UQ0-1; Sequence=Displayed; Name=2; Synonyms=SZF1-2; IsoId=Q86UQ0-2; Sequence=VSP_028449, VSP_028450; Note=Probable target of nonsense-mediated mRNA decay. The proposed CDS is dubious.; Name=3; Synonyms=SZF1-1; IsoId=Q86UQ0-3; Sequence=VSP_028449, VSP_028450, VSP_028451; Note=Probable target of nonsense-mediated mRNA decay. The proposed CDS is dubious. Isoform produced through aberrant splice sites.;
DomainThe KRAB domain mediates interaction with TRIM28.
FunctionMay play a role in hematopoietic stem/progenitor cell differentiation. May play a role as a DNA binding-dependent transcriptional repressor. {ECO:0000269|PubMed:10029171, ECO:0000269|PubMed:12097288}.
Sequence CautionSequence=AAH05859.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH06247.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH48798.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the krueppel C2H2-type zinc-finger protein family. {ECO:0000305}.
SimilarityContains 1 KRAB domain. {ECO:0000255|PROSITE- ProRule:PRU00119}.
SimilarityContains 4 C2H2-type zinc fingers. {ECO:0000255|PROSITE-ProRule:PRU00042}.
Subcellular LocationNucleus {ECO:0000269|PubMed:23665872}.
SubunitInteracts with TRIM28. {ECO:0000269|PubMed:12097288}.
Tissue SpecificityIsoform 2 is widely expressed. Isoform 3 is only expressed in CD34(+) cells. {ECO:0000269|PubMed:10029171}.
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