MGP Database

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MGP005183

UniProt Annotations

Entry Information
Gene Nameangiomotin like 2
Protein EntryAMOL2_HUMAN
UniProt IDQ9Y2J4
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9Y2J4-1; Sequence=Displayed; Name=2; IsoId=Q9Y2J4-2; Sequence=VSP_015711; Name=3; IsoId=Q9Y2J4-3; Sequence=VSP_037826; Note=No experimental confirmation available.; Name=4; IsoId=Q9Y2J4-4; Sequence=VSP_044081; Note=No experimental confirmation available.;
FunctionRegulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC. {ECO:0000269|PubMed:17293535, ECO:0000269|PubMed:21937427, ECO:0000269|PubMed:22362771}.
PtmPhosphorylation at Tyr-107 is necessary for efficient binding to SRC and synergistically functioning with SRC to activate the downstream MAPK pathway. {ECO:0000250}.
Sequence CautionSequence=AAH11454.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA76833.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD97318.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the angiomotin family. {ECO:0000305}.
Subcellular LocationRecycling endosome {ECO:0000250}.
SubunitInteracts with SRC. {ECO:0000269|PubMed:17293535}.
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