MGP Database

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MGP005208

UniProt Annotations

Entry Information
Gene Nameglycerophosphodiester phosphodiesterase 1
Protein EntryGDE1_HUMAN
UniProt IDQ9NZC3
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity1-(sn-glycero-3-phospho)-1D-myo-inositol + H(2)O = myo-inositol + sn-glycerol 3-phosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
FunctionHas glycerophosphoinositol phosphodiesterase activity. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity). {ECO:0000250}.
PtmN-glycosylated. {ECO:0000250}.
Sequence CautionSequence=AAC05440.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAC05803.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the glycerophosphoryl diester phosphodiesterase family. {ECO:0000305}.
SimilarityContains 1 GP-PDE domain. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Perinuclear vesicles and cell membrane. {ECO:0000250}.
SubunitInteracts with RGS16 (By similarity). Interacts with PRAF2. {ECO:0000250, ECO:0000269|PubMed:16472945}.
Tissue SpecificityWidely expressed. {ECO:0000269|PubMed:10760272}.
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