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MGP005225

UniProt Annotations

Entry Information
Gene NameGINS complex subunit 2 (Psf2 homolog)
Protein EntryPSF2_HUMAN
UniProt IDQ9Y248
SpeciesHuman
Comments
Comment typeDescription
FunctionThe GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA. {ECO:0000269|PubMed:17417653}.
InteractionO96017:CHEK2; NbExp=2; IntAct=EBI-747491, EBI-1180783; Q9BTE3:MCMBP; NbExp=2; IntAct=EBI-747491, EBI-749378;
Mass SpectrometryMass=98373; Mass_error=13; Method=Electrospray; Range=1-185; Note=This is the measured mass for the GINS complex.; Evidence={ECO:0000269|PubMed:17557111};
SimilarityBelongs to the GINS2/PSF2 family. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000250}.
SubunitComponent of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS3. GINS complex interacts with DNA primase in vitro. {ECO:0000269|PubMed:17417653, ECO:0000269|PubMed:17545466, ECO:0000269|PubMed:17557111, ECO:0000269|PubMed:17652513}.
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