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MGP005238

UniProt Annotations

Entry Information
Gene Namecalcium binding protein 39
Protein EntryCAB39_HUMAN
UniProt IDQ9Y376
SpeciesHuman
Comments
Comment typeDescription
FunctionComponent of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1. {ECO:0000269|PubMed:19892943}.
InteractionQ9P289:MST4; NbExp=6; IntAct=EBI-306905, EBI-618239; O95747:OXSR1; NbExp=3; IntAct=EBI-306905, EBI-620853; Q15831:STK11; NbExp=5; IntAct=EBI-306905, EBI-306838; O00506:STK25; NbExp=3; IntAct=EBI-306905, EBI-618295; Q9UEW8:STK39; NbExp=4; IntAct=EBI-306905, EBI-2680974; Q7RTN6:STRADA; NbExp=3; IntAct=EBI-306905, EBI-1109114; Q9C0K7:STRADB; NbExp=5; IntAct=EBI-306905, EBI-306893;
SimilarityBelongs to the Mo25 family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000305}.
SubunitComponent of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. {ECO:0000269|PubMed:19892943}.
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