MGP Database

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MGP005240

UniProt Annotations

Entry Information
Gene Namecytidine monophosphate (UMP-CMP) kinase 1, cytosolic
Protein EntryKCY_HUMAN
UniProt IDP30085
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P30085-1; Sequence=Displayed; Name=2; IsoId=P30085-2; Sequence=VSP_046683;
Catalytic ActivityATP + (d)CMP = ADP + (d)CDP. {ECO:0000255|HAMAP-Rule:MF_03172}.
Catalytic ActivityATP + nucleoside diphosphate = ADP + nucleoside triphosphate. {ECO:0000255|HAMAP-Rule:MF_03172}.
Catalytic ActivityATP + UMP = ADP + UDP. {ECO:0000255|HAMAP- Rule:MF_03172}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per monomer.;
DomainConsists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
FunctionCatalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000255|HAMAP-Rule:MF_03172, ECO:0000269|PubMed:10462544, ECO:0000269|PubMed:11912132, ECO:0000269|PubMed:23416111}.
Sequence CautionSequence=AAF17709.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH14961.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD96734.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG60709.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI13471.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI14972.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the adenylate kinase family. UMP-CMP kinase subfamily. {ECO:0000255|HAMAP-Rule:MF_03172}.
Subcellular LocationNucleus. Cytoplasm. Note=Predominantly nuclear.
SubunitMonomer. {ECO:0000255|HAMAP-Rule:MF_03172}.
Tissue SpecificityUbiquitously expressed. {ECO:0000269|PubMed:11681623}.
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