MGP Database

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MGP005244

UniProt Annotations

Entry Information
Gene NameAT rich interactive domain 4B (RBP1-like)
Protein EntryARI4B_HUMAN
UniProt IDQ4LE39
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q4LE39-1; Sequence=Displayed; Name=2; IsoId=Q4LE39-2; Sequence=VSP_024231; Name=3; IsoId=Q4LE39-3; Sequence=VSP_024234, VSP_024235; Name=4; IsoId=Q4LE39-4; Sequence=VSP_024230, VSP_024232, VSP_024233;
DomainThe ARID domain is involved in stabilizing the mSin3A corepressor complex on DNA. {ECO:0000269|PubMed:12724404}.
DomainThe C-terminus mediates interaction with mSin3A corepressor complex. {ECO:0000269|PubMed:12724404}.
DomainThe N-terminus is involved in transcriptional repression by HDAC-independent mechanisms. {ECO:0000269|PubMed:12724404}.
FunctionActs as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. {ECO:0000269|PubMed:12724404}.
InteractionP14921:ETS1; NbExp=2; IntAct=EBI-2680990, EBI-913209;
Sequence CautionSequence=AAD41239.1; Type=Frameshift; Positions=859, 869, 1287, 1311; Evidence={ECO:0000305}; Sequence=AAF23433.3; Type=Frameshift; Positions=1287, 1311; Evidence={ECO:0000305}; Sequence=BAB14428.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAE06114.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI13751.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityContains 1 ARID domain. {ECO:0000255|PROSITE- ProRule:PRU00355}.
Subcellular LocationNucleus {ECO:0000255|PROSITE- ProRule:PRU00355}. Cytoplasm {ECO:0000269|PubMed:11481388, ECO:0000269|PubMed:15247124}. Note=Cytoplasmic in breast cancer cells.
SubunitComponent of a Sin3A corepressor complex consisting of SIN3A, SAP130, SUDS3/SAP45, SAP180, HDAC1 and HDAC2. {ECO:0000269|PubMed:12724404}.
Tissue SpecificityHighly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary. {ECO:0000269|PubMed:11481388, ECO:0000269|PubMed:12724404, ECO:0000269|PubMed:15247124}.
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