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MGP005255

UniProt Annotations

Entry Information
Gene Namepolypeptide N-acetylgalactosaminyltransferase 7
Protein EntryGALT7_HUMAN
UniProt IDQ86SF2
SpeciesHuman
Comments
Comment typeDescription
CofactorName=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
DomainThere are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding. {ECO:0000250}.
DomainThe ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity. {ECO:0000250}.
FunctionGlycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified.
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the glycosyltransferase 2 family. GalNAc-T subfamily. {ECO:0000305}.
SimilarityContains 1 ricin B-type lectin domain. {ECO:0000255|PROSITE-ProRule:PRU00174}.
Subcellular LocationGolgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Tissue SpecificityWidely expressed. Expressed in uterus, retina, kidney, small intestine, omentum, stomach and CNS. {ECO:0000269|PubMed:10544240}.
Web ResourceName=Functional Glycomics Gateway - GTase; Note=N- acetylgalactosaminyltransferase 7; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_489";
Web ResourceName=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=GALNT7";
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