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MGP005259

UniProt Annotations

Entry Information
Gene Nametwo pore segment channel 1
Protein EntryTPC1_HUMAN
UniProt IDQ9ULQ1
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9ULQ1-1; Sequence=Displayed; Name=2; IsoId=Q9ULQ1-2; Sequence=VSP_023003, VSP_023004, VSP_023005; Name=3; IsoId=Q9ULQ1-3; Sequence=VSP_041346;
DomainEach of the two internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position (By similarity). {ECO:0000250}.
FunctionNicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane. {ECO:0000269|PubMed:19620632}.
InteractionSelf; NbExp=3; IntAct=EBI-5239895, EBI-5239895; O00165:HAX1; NbExp=2; IntAct=EBI-5239895, EBI-357001; Q8NHX9:TPCN2; NbExp=9; IntAct=EBI-5239895, EBI-5239949;
Sequence CautionSequence=AK057414; Type=Frameshift; Positions=273; Evidence={ECO:0000305}; Sequence=BAA86483.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily. {ECO:0000305}.
Subcellular LocationLysosome membrane {ECO:0000269|PubMed:19620632}; Multi-pass membrane protein {ECO:0000269|PubMed:19620632}. Endosome membrane {ECO:0000269|PubMed:19620632}; Multi-pass membrane protein {ECO:0000269|PubMed:19620632}.
SubunitDimer. {ECO:0000305}.
Tissue SpecificityHighest expression found in the heart and kidney, and lowest expression found in the spleen. {ECO:0000269|PubMed:10574461}.
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