MGP Database

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MGP005274

UniProt Annotations

Entry Information
Gene NameN-acetylneuraminic acid synthase
Protein EntrySIAS_HUMAN
UniProt IDQ9NR45
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityPhosphoenolpyruvate + N-acetyl-D-mannosamine + H(2)O = phosphate + N-acetylneuraminate.
Catalytic ActivityPhosphoenolpyruvate + N-acyl-D-mannosamine 6- phosphate + H(2)O = N-acylneuraminate 9-phosphate + phosphate.
FunctionProduces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3- deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N- acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively.
SimilarityContains 1 AFP-like domain. {ECO:0000255|PROSITE- ProRule:PRU00021}.
Tissue SpecificityUbiquitous.
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