MGP Database

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MGP005278

Record overview

MGPD IDMGP005278
Gene ID54210
SpeciesHomo sapiens (Human)
Gene Nametriggering receptor expressed on myeloid cells 1
Gene Symbol TREM1
SynonymsCD354; TREM-1;
Alternate namestriggering receptor expressed on myeloid cells 1; triggering receptor expressed on monocytes 1; triggering-receptor TREM1;
Chromosome6
Map Location6p21.1
SummaryThis gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
OrthologsView orthologs and multiple alignments for TREM1

Proteins

triggering receptor expressed on myeloid cells 1 isoform 1 precursor
Refseq ID:NP_061113
Protein GI:8924262
UniProt ID:Q38L15
mRNA ID:NM_018643
Length:234
RefSeq Status:
MRKTRLWGLLWMLFVSELRAATKLTEEKYELKEGQTLDVKCDYTLEKFASSQKAWQIIRDGEMPKTLACTERPSKNSHPVQVGRIILEDYHDHGLLRVRM
VNLQVEDSGLYQCVIYQPPKEPHMLFDRIRLVVTKGFSGTPGSNENSTQNVYKIPPTTTKALCPLYTSPRTVTQAPPKSTADVSTPDSEINLTNVTDIIR
VPVFNIVILLAGGFLSKSLVFSVLFAVTLRSFVP
 
sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2507
peptide sequence: 
MRKTRLWGLLWMLFVSELRA

mat_peptide: 21..234
product: triggering receptor expressed on myeloid cells 1 isoform 1
calculated_mol_wt: 23898
peptide sequence: 
ATKLTEEKYELKEGQTLDVKCDYTLEKFASSQKAWQIIRDGEMPKTLACTERPSKNSHPVQVGRIILEDYHDHGLLRVRMVNLQVEDSGLYQCVIYQPPK
EPHMLFDRIRLVVTKGFSGTPGSNENSTQNVYKIPPTTTKALCPLYTSPRTVTQAPPKSTADVSTPDSEINLTNVTDIIRVPVFNIVILLAGGFLSKSLV
FSVLFAVTLRSFVP
 
triggering receptor expressed on myeloid cells 1 isoform 2 precursor
Refseq ID:NP_001229518
Protein GI:336088680
UniProt ID:Q9NP99
mRNA ID:NM_001242589
Length:225
RefSeq Status:
MRKTRLWGLLWMLFVSELRAATKLTEEKYELKEGQTLDVKCDYTLEKFASSQKAWQIIRDGEMPKTLACTERPSKNSHPVQVGRIILEDYHDHGLLRVRM
VNLQVEDSGLYQCVIYQPPKEPHMLFDRIRLVVTKGFSGTPGSNENSTQNVYKIPPTTTKALCPLYTSPRTVTQAPPKSTADVSTPDSEINLTNVTDIIR
YSFQVPGPLVWTLSPLFPSLCAERM
 
sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2507
peptide sequence: 
MRKTRLWGLLWMLFVSELRA

mat_peptide: 21..234
product: triggering receptor expressed on myeloid cells 1 isoform 1
calculated_mol_wt: 23898
peptide sequence: 
ATKLTEEKYELKEGQTLDVKCDYTLEKFASSQKAWQIIRDGEMPKTLACTERPSKNSHPVQVGRIILEDYHDHGLLRVRMVNLQVEDSGLYQCVIYQPPK
EPHMLFDRIRLVVTKGFSGTPGSNENSTQNVYKIPPTTTKALCPLYTSPRTVTQAPPKSTADVSTPDSEINLTNVTDIIRVPVFNIVILLAGGFLSKSLV
FSVLFAVTLRSFVP

sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2507
peptide sequence: 
MRKTRLWGLLWMLFVSELRA

mat_peptide: 21..150
product: triggering receptor expressed on myeloid cells 1 isoform 3
calculated_mol_wt: 15074
peptide sequence: 
ATKLTEEKYELKEGQTLDVKCDYTLEKFASSQKAWQIIRDGEMPKTLACTERPSKNSHPVQVGRIILEDYHDHGLLRVRMVNLQVEDSGLYQCVIYQPPK
EPHMLFDRIRLVVTKGFRCSTLSFSWLVDS

sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2507
peptide sequence: 
MRKTRLWGLLWMLFVSELRA

mat_peptide: 21..225
product: triggering receptor expressed on myeloid cells 1 isoform 2
calculated_mol_wt: 23086
peptide sequence: 
ATKLTEEKYELKEGQTLDVKCDYTLEKFASSQKAWQIIRDGEMPKTLACTERPSKNSHPVQVGRIILEDYHDHGLLRVRMVNLQVEDSGLYQCVIYQPPK
EPHMLFDRIRLVVTKGFSGTPGSNENSTQNVYKIPPTTTKALCPLYTSPRTVTQAPPKSTADVSTPDSEINLTNVTDIIRYSFQVPGPLVWTLSPLFPSL
CAERM
 
triggering receptor expressed on myeloid cells 1 isoform 3 precursor
Refseq ID:NP_001229519
Protein GI:336088660
UniProt ID:Q9NP99
mRNA ID:NM_001242590
Length:150
RefSeq Status:
MRKTRLWGLLWMLFVSELRAATKLTEEKYELKEGQTLDVKCDYTLEKFASSQKAWQIIRDGEMPKTLACTERPSKNSHPVQVGRIILEDYHDHGLLRVRM
VNLQVEDSGLYQCVIYQPPKEPHMLFDRIRLVVTKGFRCSTLSFSWLVDS
 
sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2507
peptide sequence: 
MRKTRLWGLLWMLFVSELRA

mat_peptide: 21..234
product: triggering receptor expressed on myeloid cells 1 isoform 1
calculated_mol_wt: 23898
peptide sequence: 
ATKLTEEKYELKEGQTLDVKCDYTLEKFASSQKAWQIIRDGEMPKTLACTERPSKNSHPVQVGRIILEDYHDHGLLRVRMVNLQVEDSGLYQCVIYQPPK
EPHMLFDRIRLVVTKGFSGTPGSNENSTQNVYKIPPTTTKALCPLYTSPRTVTQAPPKSTADVSTPDSEINLTNVTDIIRVPVFNIVILLAGGFLSKSLV
FSVLFAVTLRSFVP

sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2507
peptide sequence: 
MRKTRLWGLLWMLFVSELRA

mat_peptide: 21..150
product: triggering receptor expressed on myeloid cells 1 isoform 3
calculated_mol_wt: 15074
peptide sequence: 
ATKLTEEKYELKEGQTLDVKCDYTLEKFASSQKAWQIIRDGEMPKTLACTERPSKNSHPVQVGRIILEDYHDHGLLRVRMVNLQVEDSGLYQCVIYQPPK
EPHMLFDRIRLVVTKGFRCSTLSFSWLVDS
 
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