MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP005283

UniProt Annotations

Entry Information
Gene Nametelomeric repeat binding factor 2, interacting protein
Protein EntryTE2IP_HUMAN
UniProt IDQ9NYB0
SpeciesHuman
Comments
Comment typeDescription
CautionWas reported to participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair in the absence of TERF2 (PubMed:19763083). However, this probably does not corresponds to its primary function and experiments in mouse showed that it is dispensible for such process and is required for repressiion of homology-directed repair (HDR). {ECO:0000305|PubMed:19763083}.
FunctionActs both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'- TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. {ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:19763083}.
InteractionQ8IY92:SLX4; NbExp=4; IntAct=EBI-750109, EBI-2370740; Q15554:TERF2; NbExp=7; IntAct=EBI-750109, EBI-706637; Q9BSI4-3:TINF2; NbExp=3; IntAct=EBI-750109, EBI-717418;
MiscellaneousShares a bidirectional promoter with KARS. {ECO:0000305|PubMed:14659874}.
Sequence CautionSequence=AAL55783.1; Type=Frameshift; Positions=151; Evidence={ECO:0000305}; Sequence=BAA91317.1; Type=Erroneous termination; Positions=299; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=BAG60996.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the RAP1 family. {ECO:0000305}.
SimilarityContains 1 BRCT domain. {ECO:0000305}.
SimilarityContains 1 Myb-like domain. {ECO:0000305}.
Subcellular LocationNucleus. Cytoplasm {ECO:0000250}. Chromosome. Chromosome, telomere. Note=Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex (By similarity). {ECO:0000250}.
SubunitAssociates with the I-kappa-B-kinase (IKK) core complex, composed of CHUK, IKBKB and IKBKG (By similarity). Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Interacts with TERF2; the interaction is direct. Does not interact with TERF1. Interacts with SLX4/BTBD12. {ECO:0000250, ECO:0000269|PubMed:15316005, ECO:0000269|PubMed:15383534, ECO:0000269|PubMed:19596235}.
Tissue SpecificityUbiquitous. Highly expressed.
  logo