MGP Database

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MGP005296

Ontology/Pathway Information

Entrez Gene ID54512
Gene Nameexosome component 4
Gene Symbol EXOSC4
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0000178 IDA:UniProtKBCexosome (RNase complex)
GO:0005730 NAS:UniProtKBCnucleolus
GO:0005634 IDA:UniProtKBCnucleus
GO:0035327 IMP:UniProtKBCtranscriptionally active chromatin
GO:0000175 NAS:UniProtKBF3'-5'-exoribonuclease activity
GO:0017091 IDA:UniProtKBFAU-rich element binding
GO:0051607 IMP:MGIPdefense response to virus
GO:0045006 IDA:UniProtKBPDNA deamination
GO:0043928 TAS:ReactomePexonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0010467 TAS:ReactomePgene expression
GO:0071044 IMP:UniProtKBPhistone mRNA catabolic process
GO:0000460 IMP:UniProtKBPmaturation of 5.8S rRNA
GO:0016071 TAS:ReactomePmRNA metabolic process
GO:0071028 IMP:UniProtKBPnuclear mRNA surveillance
GO:0000956 IMP:UniProtKBPnuclear-transcribed mRNA catabolic process
GO:0000288 TAS:ReactomePnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0030307 IMP:UniProtKBPpositive regulation of cell growth
GO:0016070 TAS:ReactomePRNA metabolic process
GO:0090503 NAS:GOCPRNA phosphodiester bond hydrolysis, exonucleolytic
GO:0006364 NAS:UniProtKBPrRNA processing
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_18355ATF4 activates genes
REACT_24915Butyrate Response Factor 1 (BRF1) destabilizes mRNA
REACT_20639Deadenylation-dependent mRNA decay
REACT_71Gene Expression
REACT_25042KSRP destabilizes mRNA
REACT_17015Metabolism of proteins
REACT_20619mRNA decay by 3' to 5' exoribonuclease
REACT_18277PERK regulates gene expression
REACT_24994Regulation of mRNA stability by proteins that bind AU-rich elements
REACT_25064Tristetraprolin (TTP) destabilizes mRNA
REACT_18356Unfolded Protein Response (UPR)
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