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MGP005309

Record overview

MGPD IDMGP005309
Gene ID54579
SpeciesHomo sapiens (Human)
Gene NameUDP glucuronosyltransferase 1 family, polypeptide A5
Gene Symbol UGT1A5
SynonymsUDPGT; UGT1E; UDPGT 1-5;
Alternate namesUDP-glucuronosyltransferase 1-5; UDP glycosyltransferase 1 family, polypeptide A5; UDP-glucuronosyltransferase 1 family polypeptide A5s; UDP-glucuronosyltransferase 1-E; UDP-glucuronosyltransferase 1A5; UGT-1E; UGT1*5;
Chromosome2
Map Location2q37
EC Number2.4.1.17
SummaryThis gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for UGT1A5

Proteins

UDP-glucuronosyltransferase 1-5 precursor
Refseq ID:NP_061951
Protein GI:46249404
UniProt ID:P35504
mRNA ID:NM_019078
Length:534
RefSeq Status:
MATGLQVPLPQLATGLLLLLSVQPWAESGKVLVVPTDGSHWLSMREALRDLHARGHQVVVLTLEVNMYIKEENFFTLTTYAISWTQDEFDRLLLGHTQSF
FETEHLLMKFSRRMAIMNNMSLIIHRSCVELLHNEALIRHLHATSFDVVLTDPFHLCAAVLAKYLSIPAVFFLRNIPCDLDFKGTQCPNPSSYIPRLLTT
NSDHMTFLQRVKNMLYPLALSYLCHAVSAPYASLASELFQREVSVVDLVSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGE
HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMD
NAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVV
LTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
 
sig_peptide: 1..28
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2948
peptide sequence: 
MATGLQVPLPQLATGLLLLLSVQPWAES

mat_peptide: 29..534
product: UDP-glucuronosyltransferase 1-5
calculated_mol_wt: 57142
peptide sequence: 
GKVLVVPTDGSHWLSMREALRDLHARGHQVVVLTLEVNMYIKEENFFTLTTYAISWTQDEFDRLLLGHTQSFFETEHLLMKFSRRMAIMNNMSLIIHRSC
VELLHNEALIRHLHATSFDVVLTDPFHLCAAVLAKYLSIPAVFFLRNIPCDLDFKGTQCPNPSSYIPRLLTTNSDHMTFLQRVKNMLYPLALSYLCHAVS
APYASLASELFQREVSVVDLVSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALG
KIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENAL
KAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKA
HKSKTH
 
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