MGP Database

MGP005314

Ontology/Pathway Information

Entrez Gene ID	54658
Gene Name	UDP glucuronosyltransferase 1 family, polypeptide A1
Gene Symbol	UGT1A1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0070069	IEA:Ensembl	C	cytochrome complex
GO:0005783	IDA:UniProtKB	C	endoplasmic reticulum
GO:0005789	IBA:GO_Central	C	endoplasmic reticulum membrane
GO:0005887	IEA:Ensembl	C	integral component of plasma membrane
GO:0019899	IPI:BHF-UCL	F	enzyme binding
GO:0004857	IDA:BHF-UCL	F	enzyme inhibitor activity
GO:0015020	IDA:UniProtKB	F	glucuronosyltransferase activity
GO:0046982	IDA:UniProtKB	F	protein heterodimerization activity
GO:0042803	IDA:UniProtKB	F	protein homodimerization activity
GO:0001972	IDA:BHF-UCL	F	retinoic acid binding
GO:0005496	IDA:BHF-UCL	F	steroid binding
GO:0006953	IEA:Ensembl	P	acute-phase response
GO:0006789	TAS:ProtInc	P	bilirubin conjugation
GO:0070980	IEA:Ensembl	P	biphenyl catabolic process
GO:0052695	IDA:UniProtKB	P	cellular glucuronidation
GO:0071361	IEA:Ensembl	P	cellular response to ethanol
GO:0071385	IEA:Ensembl	P	cellular response to glucocorticoid stimulus
GO:0032870	IBA:GO_Central	P	cellular response to hormone stimulus
GO:0007586	NAS:ProtInc	P	digestion
GO:0017144	IC:BHF-UCL	P	drug metabolic process
GO:0008210	TAS:ProtInc	P	estrogen metabolic process
GO:0051552	IDA:BHF-UCL	P	flavone metabolic process
GO:0009813	IBA:GO_Central	P	flavonoid biosynthetic process
GO:0052696	IDA:BHF-UCL	P	flavonoid glucuronidation
GO:0042167	TAS:Reactome	P	heme catabolic process
GO:0046483	IC:BHF-UCL	P	heterocycle metabolic process
GO:0001889	IEA:Ensembl	P	liver development
GO:0043086	IDA:GOC	P	negative regulation of catalytic activity
GO:2001030	IDA:UniProtKB	P	negative regulation of cellular glucuronidation
GO:0045939	IC:BHF-UCL	P	negative regulation of steroid metabolic process
GO:0031100	IEA:Ensembl	P	organ regeneration
GO:0006778	TAS:Reactome	P	porphyrin-containing compound metabolic process
GO:0042493	IEA:Ensembl	P	response to drug
GO:0032496	IEA:Ensembl	P	response to lipopolysaccharide
GO:0007584	IEA:Ensembl	P	response to nutrient
GO:0042594	IEA:Ensembl	P	response to starvation
GO:0042573	IC:BHF-UCL	P	retinoic acid metabolic process
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0008202	IC:BHF-UCL	P	steroid metabolic process
GO:0052697	IDA:BHF-UCL	P	xenobiotic glucuronidation
GO:0006805	TAS:Reactome	P	xenobiotic metabolic process

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_13433	Biological oxidations
REACT_268587	Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)
REACT_268321	Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)
REACT_268129	Defective GGT1 causes Glutathionuria (GLUTH)
REACT_267887	Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
REACT_268063	Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD)
REACT_268256	Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)
REACT_267818	Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD)
REACT_268027	Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency)
REACT_268058	Defective UGT1A1 causes hyperbilirubinemia
REACT_268618	Defective UGT1A4 causes hyperbilirubinemia
REACT_116125	Disease
REACT_6784	Glucuronidation
REACT_22297	Heme degradation
REACT_267615	Metabolic disorders of biological oxidation enzymes
REACT_111217	Metabolism
REACT_9431	Metabolism of porphyrins
REACT_6959	Phase II conjugation

SMP Pathway Links

SMP ID	Description
SMP00640	Acetaminophen Metabolism Pathway
SMP00442	Etoposide Action Pathway
SMP00601	Etoposide Metabolism Pathway
SMP00086	Ibuprofen Action Pathway
SMP00590	Ibuprofen Metabolism Pathway
SMP00433	Irinotecan Action Pathway
SMP00600	Irinotecan Metabolism Pathway
SMP00406	Morphine Action Pathway
SMP00622	Morphine Metabolism Pathway
SMP00327	Phenytoin (Antiarrhythmic) Action Pathway
SMP00074	Retinol Metabolism
SMP00648	Sorafenib Metabolism Pathway
SMP00336	Vitamin A Deficiency