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MGP005321

Record overview

MGPD IDMGP005321
Gene ID54739
SpeciesHomo sapiens (Human)
Gene NameXIAP associated factor 1
Gene Symbol XAF1
SynonymsBIRC4BP; XIAPAF1; HSXIAPAF1;
Alternate namesXIAP-associated factor 1; BIRC4 binding protein; BIRC4-binding protein;
Chromosome17
Map Location17p13.1
SummaryThis gene encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during apoptosis. The proportion of IAPs and proteins which interfere with their activity, such as the encoded protein, affect the progress of the apoptosis signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
OrthologsView orthologs and multiple alignments for XAF1

Proteins

XIAP-associated factor 1 isoform 1
Refseq ID:NP_059993
Protein GI:40288191
UniProt ID:Q6GPH4
mRNA ID:NM_017523
Length:301
RefSeq Status:
MEGDFSVCRNCKRHVVSANFTLHEAYCLRFLVLCPECEEPVPKETMEEHCKLEHQQVGCTMCQQSMQKSSLEFHKANECQERPVECKFCKLDMQLSKLEL
HESYCGSRTELCQGCGQFIMHRMLAQHRDVCRSEQAQLGKGERISAPEREIYCHYCNQMIPENKYFHHMGKCCPDSEFKKHFPVGNPEILPSSLPSQAAE
NQTSTMEKDVRPKTRSINRFPLHSESSSKKAPRSKNKTLDPLLMSEPKPRTSSPRGDKAAYDILRRCSQCGILLPLPILNQHQEKCRWLASSKGKQVRNF
S
 
XIAP-associated factor 1 isoform 2
Refseq ID:NP_954590
Protein GI:40288193
UniProt ID:Q6GPH4
mRNA ID:NM_199139
Length:282
RefSeq Status:
MEGDFSVCRNCKRHVVSANFTLHEAYCLRFLVLCPECEEPVPKETMEEHCKLEHQQANECQERPVECKFCKLDMQLSKLELHESYCGSRTELCQGCGQFI
MHRMLAQHRDVCRSEQAQLGKGERISAPEREIYCHYCNQMIPENKYFHHMGKCCPDSEFKKHFPVGNPEILPSSLPSQAAENQTSTMEKDVRPKTRSINR
FPLHSESSSKKAPRSKNKTLDPLLMSEPKPRTSSPRGDKAAYDILRRCSQCGILLPLPILNQHQEKCRWLASSKGKQVRNFS
 
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