MGP Database

MGP005333

Record overview

MGPD ID	MGP005333
Gene ID	54829
Species	Homo sapiens (Human)
Gene Name	asporin
Gene Symbol	ASPN
Synonyms	OS3; PLAP1; PLAP-1; SLRR1C;
Alternate names	asporin; asporin (LRR class 1); asporin proteoglycan; periodontal ligament associated protein 1; small leucine-rich protein 1C;
Chromosome	9
Map Location	9q22
Summary	This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis, and also with intervertebral disc disease. Alternative splicing of this gene results in multiple transcript variants.[provided by RefSeq, Jul 2014]
Orthologs	View orthologs and multiple alignments for ASPN

Proteins

asporin isoform 1 preproprotein

Refseq ID:	NP_060150
Protein GI:	301069322
UniProt ID:	Q6P528
mRNA ID:	NM_017680
Length:	379
RefSeq Status:

`MKEYVLLLFLALCSAKPFFSPSHIALKNMMLKDMEDTDDDDDDDDDDDDDEDNSLFPTREPRSHFFPFDLFPMCPFGCQCYSRVVHCSDLGLTSVPTNIP FDTRMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLE MSANPLDNNGIEPGAFEGVTVFHIRIAEAKLTSVPKGLPPTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHLENNKL KKIPSGLPELKYLQIIFLHSNSIARVGVNDFCPTVPKMKKSLYSAISLFNNPVKYWEMQPATFRCVLSRMSVQLGNFGM`

sig_peptide: 1..15
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1714
peptide sequence: 
MKEYVLLLFLALCSA

mat_peptide: 33..242
product: asporin isoform 2
calculated_mol_wt: 23966
peptide sequence: 
DMEDTDDDDDDDDDDDDDEDNSLFPTREPRSHFFPFDLFPMCPFGCQCYSRVVHCSDLGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLIL
NNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHIRIAEAKLT
SVPKDNLPSF

sig_peptide: 1..15
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1714
peptide sequence: 
MKEYVLLLFLALCSA

mat_peptide: 33..379
product: asporin isoform 1
calculated_mol_wt: 39635
peptide sequence: 
DMEDTDDDDDDDDDDDDDEDNSLFPTREPRSHFFPFDLFPMCPFGCQCYSRVVHCSDLGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLIL
NNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHIRIAEAKLT
SVPKGLPPTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHLENNKLKKIPSGLPELKYLQIIFLHSNSIARVGVNDFC
PTVPKMKKSLYSAISLFNNPVKYWEMQPATFRCVLSRMSVQLGNFGM

asporin isoform 2 preproprotein

Refseq ID:	NP_001180264
Protein GI:	301069324
UniProt ID:	Q9BXN1
mRNA ID:	NM_001193335
Length:	242
RefSeq Status:

`MKEYVLLLFLALCSAKPFFSPSHIALKNMMLKDMEDTDDDDDDDDDDDDDEDNSLFPTREPRSHFFPFDLFPMCPFGCQCYSRVVHCSDLGLTSVPTNIP FDTRMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLE MSANPLDNNGIEPGAFEGVTVFHIRIAEAKLTSVPKDNLPSF`

sig_peptide: 1..15
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1714
peptide sequence: 
MKEYVLLLFLALCSA

mat_peptide: 33..242
product: asporin isoform 2
calculated_mol_wt: 23966
peptide sequence: 
DMEDTDDDDDDDDDDDDDEDNSLFPTREPRSHFFPFDLFPMCPFGCQCYSRVVHCSDLGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLIL
NNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHIRIAEAKLT
SVPKDNLPSF