MGP Database

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MGP005341

UniProt Annotations

Entry Information
Gene NameELOVL fatty acid elongase 2
Protein EntryELOV2_HUMAN
UniProt IDQ9NXB9
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityA very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO(2). {ECO:0000269|PubMed:12371743, ECO:0000269|PubMed:20937905}.
DomainThe di-lysine motif may confer endoplasmic reticulum localization. {ECO:0000250}.
FunctionCondensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. {ECO:0000269|PubMed:12371743, ECO:0000269|PubMed:20937905}.
PathwayLipid metabolism; polyunsaturated fatty acid biosynthesis. {ECO:0000269|PubMed:12371743, ECO:0000269|PubMed:20937905}.
SimilarityBelongs to the ELO family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:20937905}; Multi-pass membrane protein {ECO:0000269|PubMed:20937905}.
Tissue SpecificityLiver and testis. {ECO:0000269|PubMed:20937905}.
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