MGP Database

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MGP005357

UniProt Annotations

Entry Information
Gene Nameacyl-CoA synthetase medium-chain family member 5
Protein EntryACSM5_HUMAN
UniProt IDQ6NUN0
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6NUN0-1; Sequence=Displayed; Name=2; IsoId=Q6NUN0-2; Sequence=VSP_028398; Note=No experimental confirmation available.;
Catalytic ActivityATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
FunctionHas medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity). {ECO:0000250}.
Sequence CautionSequence=BAA91273.1; Type=Frameshift; Positions=560; Evidence={ECO:0000305};
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.
Subcellular LocationMitochondrion matrix {ECO:0000250}.
Tissue SpecificityDetected in kidney and liver. {ECO:0000269|PubMed:12654705}.
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