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MGP005360

Record overview

MGPD IDMGP005360
Gene ID55033
SpeciesHomo sapiens (Human)
Gene NameFK506 binding protein 14, 22 kDa
Gene Symbol FKBP14
SynonymsEDSKMH; FKBP22; IPBP12;
Alternate namespeptidyl-prolyl cis-trans isomerase FKBP14; 22 kDa FK506-binding protein; 22 kDa FKBP; FK506-binding protein 14; FKBP-22; PPIase FKBP14; rotamase;
Chromosome7
Map Location7p14.3
EC Number5.2.1.8
SummaryThe protein encoded by this gene is a member of the FK506-binding protein family of peptidyl-prolyl cis-trans isomerases. The encoded protein is found in the lumen of the endoplasmic reticulum, where it is thought to accelerate protein folding. Defects in this gene are a cause of a type of Ehlers-Danlos syndrome (EDS). Both a protein-coding variant and noncoding variants are transcribed from this gene. [provided by RefSeq, Mar 2012]
OrthologsView orthologs and multiple alignments for FKBP14

Proteins

peptidyl-prolyl cis-trans isomerase FKBP14 precursor
Refseq ID:NP_060416
Protein GI:8923659
UniProt ID:Q9NWM8
mRNA ID:NM_017946
Length:211
RefSeq Status:
MRLFLWNAVLTLFVTSLIGALIPEPEVKIEVLQKPFICHRKTKGGDLMLVHYEGYLEKDGSLFHSTHKHNNGQPIWFTLGILEALKGWDQGLKGMCVGEK
RKLIIPPALGYGKEGKGKIPPESTLIFNIDLLEIRNGPRSHESFQEMDLNDDWKLSKDEVKAYLKKEFEKHGAVVNESHHDALVEDIFDKEDEDKDGFIS
AREFTYKHDEL
 
sig_peptide: 1..19
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2195
peptide sequence: 
MRLFLWNAVLTLFVTSLIG

mat_peptide: 20..211
product: Peptidyl-prolyl cis-trans isomerase FKBP14
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q9NWM8.1)
calculated_mol_wt: 21995
peptide sequence: 
ALIPEPEVKIEVLQKPFICHRKTKGGDLMLVHYEGYLEKDGSLFHSTHKHNNGQPIWFTLGILEALKGWDQGLKGMCVGEKRKLIIPPALGYGKEGKGKI
PPESTLIFNIDLLEIRNGPRSHESFQEMDLNDDWKLSKDEVKAYLKKEFEKHGAVVNESHHDALVEDIFDKEDEDKDGFISAREFTYKHDEL
 
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