MGP Database

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MGP005366

Record overview

MGPD IDMGP005366
Gene ID55062
SpeciesHomo sapiens (Human)
Gene NameWD repeat domain, phosphoinositide interacting 1
Gene Symbol WIPI1
SynonymsATG18; ATG18A; WIPI49;
Alternate namesWD repeat domain phosphoinositide-interacting protein 1; WD40 repeat protein Interacting with phosphoInositides of 49kDa; WD40 repeat protein interacting with phosphoinositides of 49 kDa; WIPI 49 kDa; WIPI-1 alpha; atg18 protein homolog;
Chromosome17
Map Location17q24.2
SummaryWD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI1, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM, Mar 2008]
OrthologsView orthologs and multiple alignments for WIPI1

Proteins

WD repeat domain phosphoinositide-interacting protein 1
Refseq ID:NP_060453
Protein GI:157388939
UniProt ID:Q5MNZ9
mRNA ID:NM_017983
Length:446
RefSeq Status:
MEAEAADAPPGGVESALSCFSFNQDCTSLATGTKAGYKLFSLSSVEQLDQVHGSNEIPDVYIVERLFSSSLVVVVSHTKPRQMNVYHFKKGTEICNYSYS
SNILSIRLNRQRLLVCLEESIYIHNIKDMKLLKTLLDIPANPTGLCALSINHSNSYLAYPGSLTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGSK
LASASEKGTVIRVFSVPDGQKLYEFRRGMKRYVTISSLVFSMDSQFLCASSNTETVHIFKLEQVTNSRPEEPSTWSGYMGKMFMAATNYLPTQVSDMMHQ
DRAFATARLNFSGQRNICTLSTIQKLPRLLVASSSGHLYMYNLDPQDGGECVLIKTHSLLGSGTTEENKENDLRPSLPQSYAATVARPSASSASTVPGYS
EDGGALRGEVIPEHEFATGPVCLDDENEFPPIILCRGNQKGKTKQS
 
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