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MGP005368

UniProt Annotations

Entry Information
Gene Namede-etiolated homolog 1 (Arabidopsis)
Protein EntryDET1_HUMAN
UniProt IDQ7L5Y6
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7L5Y6-1; Sequence=Displayed; Name=2; IsoId=Q7L5Y6-2; Sequence=VSP_043012; Note=No experimental confirmation available.;
FunctionComponent of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation. {ECO:0000269|PubMed:14739464}.
Sequence CautionSequence=BAA91447.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the DET1 family. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000305}.
SubunitComponent of the DCX DET1-COP1 ubiquitin ligase complex at least composed of RBX1, DET1, DDB1, CUL4A and COP1. {ECO:0000269|PubMed:14739464}.
Tissue SpecificityHighly expressed in the ovary, some lymphoid organs and resting leukocytes. {ECO:0000269|PubMed:14739464}.
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