MGP Database

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MGP005370

UniProt Annotations

Entry Information
Gene Namesolute carrier family 38, member 4
Protein EntryS38A4_HUMAN
UniProt IDQ969I6
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiespH dependence: Optimum pH is 7.5-8.5. {ECO:0000269|PubMed:11342143};
FunctionSodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium- independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5. {ECO:0000269|PubMed:11342143, ECO:0000269|PubMed:11414754}.
PtmThe disulfide bond plays an important role in substrate transport, but has no effect on trafficking to the cell surface. {ECO:0000250}.
SimilarityBelongs to the amino acid/polyamine transporter 2 family. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:11414754, ECO:0000269|PubMed:16148032}; Multi-pass membrane protein {ECO:0000269|PubMed:11414754, ECO:0000269|PubMed:16148032}.
Tissue SpecificityDetected in embryonic and adult liver, and at lower levels in adult muscle, kidney and pancreas. Detected in placenta syncytiotrophoblasts throughout gestation. Detected in fetal blood vessels. {ECO:0000269|PubMed:11342143, ECO:0000269|PubMed:11414754, ECO:0000269|PubMed:16148032}.
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