MGP Database

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MGP005403

UniProt Annotations

Entry Information
Gene NameSTEAP family member 3, metalloreductase
Protein EntrySTEA3_HUMAN
UniProt IDQ658P3
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q658P3-1; Sequence=Displayed; Name=2; IsoId=Q658P3-2; Sequence=VSP_024829; Name=3; IsoId=Q658P3-3; Sequence=VSP_024830; Name=4; Synonyms=pHyde II; IsoId=Q658P3-4; Sequence=VSP_024830, VSP_024831;
CautionWas initially thought to have tumor suppressor function in prostate cancer. However, it was shown that it is probably not the case (PubMed:12866033). {ECO:0000305|PubMed:12866033}.
CofactorName=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CofactorName=NADP(+); Xref=ChEBI:CHEBI:58349; Evidence={ECO:0000269|PubMed:18495927};
DiseaseAnemia, hypochromic microcytic, with iron overload 2 (AHMIO2) [MIM:615234]: A hematologic disease characterized by abnormal hemoglobin content in the erythrocytes which are reduced in size, severe anemia, erythropoietic hyperplasia of bone marrow, massive hepatic iron deposition, and hepatosplenomegaly. {ECO:0000269|PubMed:22031863}. Note=The disease is caused by mutations affecting the gene represented in this entry.
FunctionEndosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP. {ECO:0000269|PubMed:15319436, ECO:0000269|PubMed:16651434}.
InductionBy p53/TP53. {ECO:0000269|PubMed:12606722}.
PtmGlycosylated. {ECO:0000269|PubMed:22624035}.
PtmProteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1- induced cleavage occurs at multiple sites in a glycosylation- independent manner. {ECO:0000269|PubMed:22624035}.
SimilarityBelongs to the STEAP family. {ECO:0000305}.
SimilarityContains 1 ferric oxidoreductase domain. {ECO:0000305}.
Subcellular LocationEndosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localizes to vesicular-like structures at the plasma membrane and around the nucleus.
SubunitHomodimer. Interacts with BNIP3L, MYT1, RHBDL4/RHBDD1 and TCTP. {ECO:0000269|PubMed:12606722, ECO:0000269|PubMed:15319436, ECO:0000269|PubMed:18495927, ECO:0000269|PubMed:22624035}.
Tissue SpecificityExpressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in hepatocellular carcinoma. {ECO:0000269|PubMed:12606722, ECO:0000269|PubMed:15885357, ECO:0000269|PubMed:16227996}.
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