MGP Database

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MGP005404

UniProt Annotations

Entry Information
Gene Namesolute carrier family 47 (multidrug and toxin extrusion), member 1
Protein EntryS47A1_HUMAN
UniProt IDQ96FL8
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q96FL8-1; Sequence=Displayed; Name=2; IsoId=Q96FL8-2; Sequence=VSP_029903, VSP_029904; Note=No experimental confirmation available.; Name=3; IsoId=Q96FL8-3; Sequence=VSP_029905; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=0.38 mM for TEA {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:17509534}; KM=0.10 mM for MPP {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:17509534}; KM=0.17 mM for cimetidine {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:17509534}; KM=0.78 mM for metformin {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:17509534}; KM=2.1 mM for guanidine {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:17509534}; KM=1.23 mM for procainamide {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:17509534}; KM=0.07 mM for topotecan {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:17509534}; KM=0.47 mM for estrone sulfate {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:17509534}; KM=2.64 mM for acyclovir {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:17509534}; KM=5.12 mM for ganciclovir {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:17509534}; Vmax=1.185 nmol/min/mg enzyme toward TEA {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:17509534}; Vmax=0.735 nmol/min/mg enzyme toward MPP {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:17509534}; Vmax=0.135 nmol/min/mg enzyme toward cimetidine {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:17509534}; Vmax=2.23 nmol/min/mg enzyme toward metformin {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:17509534}; Vmax=0.89 nmol/min/mg enzyme toward guanidine {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:17509534}; Vmax=3.78 nmol/min/mg enzyme toward procainamide {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:17509534}; Vmax=0.21 nmol/min/mg enzyme toward topotecan {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:17509534}; Vmax=0.265 nmol/min/mg enzyme toward estrone sulfate {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:17509534}; Vmax=0.62 nmol/min/mg enzyme toward acyclovir {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:17509534}; Vmax=1.08 nmol/min/mg enzyme toward ganciclovir {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:17509534}; pH dependence: Optimum pH is 8.5. Active from pH 6 to 8.5. {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:17509534};
FunctionSolute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes. {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:16996621, ECO:0000269|PubMed:17495125, ECO:0000269|PubMed:17509534, ECO:0000269|PubMed:17582384}.
Sequence CautionSequence=AAH50592.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:16641166}; Multi-pass membrane protein {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:16641166}. Note=Predominantly localized at the plasma membrane but also found in intracellular organelles.
Tissue SpecificityExpressed in adrenal gland, and to a lower extent in liver, skeletal muscle and kidney (especially found in luminal membranes of the urinary tubules, bile caniculi and brush border membranes). {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:17509534}.
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