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MGP005409

UniProt Annotations

Entry Information
Gene Namephosphoglucomutase 2
Protein EntryPGM2_HUMAN
UniProt IDQ96G03
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96G03-1; Sequence=Displayed; Name=2; IsoId=Q96G03-2; Sequence=VSP_056221, VSP_056222, VSP_056223, VSP_056224; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=45.7 uM for alpha-D-ribose 1-phosphate {ECO:0000269|PubMed:17804405}; KM=4.1 uM for 2-deoxy-alpha-D-ribose 1-phosphate {ECO:0000269|PubMed:17804405}; KM=114 uM for alpha-D-glucose 1-phosphate {ECO:0000269|PubMed:17804405}; Vmax=104.3 umol/min/mg enzyme with alpha-D-ribose 1-phosphate as substrate {ECO:0000269|PubMed:17804405}; Vmax=20.8 umol/min/mg enzyme with 2-deoxy-alpha-D-ribose 1- phosphate as substrate {ECO:0000269|PubMed:17804405}; Vmax=22.8 umol/min/mg enzyme with alpha-D-glucose 1-phosphate as substrate {ECO:0000269|PubMed:17804405};
Catalytic Activity2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy- alpha-D-ribose 5-phosphate.
Catalytic ActivityAlpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.
Catalytic ActivityAlpha-D-ribose 1-phosphate = D-ribose 5- phosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000250};
FunctionCatalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. May also catalyze the interconversion of glucose-1-phosphate and glucose-6-phosphate. Has low glucose 1,6-bisphosphate synthase activity. {ECO:0000269|PubMed:17804405}.
InteractionP04792:HSPB1; NbExp=2; IntAct=EBI-4399372, EBI-352682;
PathwayCarbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2- deoxy-alpha-D-ribose 1-phosphate: step 1/2.
SimilarityBelongs to the phosphohexose mutase family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}.
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