MGP Database

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MGP005414

Ontology/Pathway Information

Entrez Gene ID55294
Gene NameF-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
Gene Symbol FBXW7
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:ParkinsonsUK-UCLCcytoplasm
GO:0005783 IEA:EnsemblCendoplasmic reticulum
GO:0005794 IEA:EnsemblCGolgi apparatus
GO:0005730 IDA:UniProtKBCnucleolus
GO:0005654 IDA:UniProtKBCnucleoplasm
GO:1990452 IPI:ParkinsonsUK-UCLCParkin-FBXW7-Cul1 ubiquitin ligase complex
GO:0043234 IDA:UniProtKBCprotein complex
GO:0019005 IDA:UniProtKBCSCF ubiquitin ligase complex
GO:0030332 IDA:ParkinsonsUK-UCLFcyclin binding
GO:0042802 IPI:IntActFidentical protein binding
GO:0030674 IDA:ParkinsonsUK-UCLFprotein binding, bridging
GO:0003700 IEA:EnsemblFsequence-specific DNA binding transcription factor activity
GO:0031625 IPI:ParkinsonsUK-UCLFubiquitin protein ligase binding
GO:0097027 IDA:ParkinsonsUK-UCLFubiquitin-protein transferase activator activity
GO:0006974 IDA:UniProtKBPcellular response to DNA damage stimulus
GO:0034644 IDA:UniProtKBPcellular response to UV
GO:0055088 ISS:BHF-UCLPlipid homeostasis
GO:0030324 IEA:EnsemblPlung development
GO:0032876 IMP:BHF-UCLPnegative regulation of DNA endoreduplication
GO:2000346 ISS:BHF-UCLPnegative regulation of hepatocyte proliferation
GO:0045746 ISS:BHF-UCLPnegative regulation of Notch signaling pathway
GO:2000639 ISS:BHF-UCLPnegative regulation of SREBP signaling pathway
GO:0010868 ISS:BHF-UCLPnegative regulation of triglyceride biosynthetic process
GO:0007219 TAS:ReactomePNotch signaling pathway
GO:0045741 IDA:BHF-UCLPpositive regulation of epidermal growth factor-activated receptor activity
GO:0070374 IMP:BHF-UCLPpositive regulation of ERK1 and ERK2 cascade
GO:1903378 IDA:ParkinsonsUK-UCLPpositive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1901800 IDA:ParkinsonsUK-UCLPpositive regulation of proteasomal protein catabolic process
GO:0031398 IDA:ParkinsonsUK-UCLPpositive regulation of protein ubiquitination
GO:2000060 IDA:BHF-UCLPpositive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051443 IDA:ParkinsonsUK-UCLPpositive regulation of ubiquitin-protein transferase activity
GO:0050821 IDA:BHF-UCLPprotein stabilization
GO:0016567 IDA:UniProtKBPprotein ubiquitination
GO:1902806 TAS:ParkinsonsUK-UCLPregulation of cell cycle G1/S phase transition
GO:0010883 ISS:BHF-UCLPregulation of lipid storage
GO:0032880 ISS:BHF-UCLPregulation of protein localization
GO:0031146 IDA:UniProtKBPSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0007062 IMP:BHF-UCLPsister chromatid cohesion
GO:0001944 TAS:BHF-UCLPvasculature development
GO:0001570 IEA:EnsemblPvasculogenesis
GO:0016032 IEA:UniProtKB-KWPviral process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_75842Antigen processing: Ubiquitination & Proteasome degradation
REACT_16907Association of TriC/CCT with target proteins during biosynthesis
REACT_17004Chaperonin-mediated protein folding
REACT_75820Class I MHC mediated antigen processing & presentation
REACT_6900Immune System
REACT_17015Metabolism of proteins
REACT_16952Protein folding
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