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MGP005428

UniProt Annotations

Entry Information
Gene Nameminichromosome maintenance complex component 10
Protein EntryMCM10_HUMAN
UniProt IDQ7L590
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7L590-1; Sequence=Displayed; Name=2; IsoId=Q7L590-2; Sequence=VSP_029951;
Developmental StageExpression is cell cycle regulated. Expression increases at the G1/S-boundary. Expression decreases in late M phase, remains low during G(1) phase, and starts to accumulate at the onset of S phase. {ECO:0000269|PubMed:11095689, ECO:0000269|PubMed:11602595}.
DomainEach zinc finger-like domain binds a zinc ion and is involved in both ssDNA and dsDNA binding, as is the OB-fold domain. {ECO:0000250}.
DomainThe N-terminal domain mediates homodimerization. {ECO:0000250}.
FunctionActs as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. {ECO:0000269|PubMed:11095689, ECO:0000269|PubMed:15136575, ECO:0000269|PubMed:17699597, ECO:0000269|PubMed:19608746}.
InteractionSelf; NbExp=2; IntAct=EBI-374912, EBI-374912; Q14566:MCM6; NbExp=2; IntAct=EBI-374912, EBI-374900; Q13416:ORC2; NbExp=5; IntAct=EBI-374912, EBI-374957;
Sequence CautionSequence=AAF69623.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the MCM10 family. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000269|PubMed:11095689, ECO:0000269|PubMed:15136575}. Note=Colocalizes with ORC2 in nuclei foci. Associated with chromatin in S phase. From early to mid-S phase located in discrete nuclear foci. In early S phase, several hundred foci appeared throughout the nucleus. In mid-S phase, the foci appeared at the nuclear periphery and nucleolar regions. In the late S and G phases localized to nucleoli.
SubunitSelf-associates (By similarity). Interacts with ORC2. May interact with MCM2 and MCM6. Interacts with the DNA polymerase alpha subunit POLA1. Interacts with RECQL4; this interaction regulates RECQL4 unwinding activity. Interacts with WDHD1. {ECO:0000250, ECO:0000269|PubMed:11095689, ECO:0000269|PubMed:17761813, ECO:0000269|PubMed:19696745}.
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